Composition:

Each 1 gm contains:

Colistin (as sulfate) …………….………… 500000 IU. 

Trimethoprim …………………………………  37.5 mg.

Properties:

Colistin is a polypeptide antibiotic belonging to the class of polymyxins. Colistin exerts a bactericidal action by disruption of the cytoplasmic membrane, leading to an alteration of cell permeability and thereby a loss of intracellular material. Colistin has a bactericidal activity against a broad spectrum of Gram-negative bacteria, including Enterobacteriaceae, in particular Escherichia coli. Colistin has very little activity against Gram-positive bacteria and fungi. The Gram-positive bacteria and some species of Gram-negative bacteria such as Proteus and Serratia are naturally resistant to colistin. However, the acquisition of resistance in Gram-negative enteric bacteria to colistin is rare and is due to single mutation.

Trimethoprim is an anti-infective that belongs to the family of diaminopyrimidines. It is active against streptococci and most Gram-negative bacteria. Trimethoprim has a bactericidal power by blocking the biosynthesis of folic acid inhibition of dihydrofolate reductase microbial.

Colistin (as sulfate) is very poorly absorbed from the gastrointestinal tract. In serum and tissue concentrations of colistin are very low. However, colistin is present in large quantities and persistently in different sections of the digestive tract.

Trimethoprim is rapidly absorbed after oral administration. It is widely distributed in the body. The combination of colistin and trimethoprim was synergic against a variety of Enterobacteriaceae negative bacteria.

Indications:

Treatment of gastrointestinal infections caused by susceptible bacteria to colistin and trimethoprim.

Target species:

Calves, lambs, goats, pigs, rabbits and poultry.

 Dosage of Administration:

Route: Orally via drinking water

Poultry: 1.5 to 2.66 g of powder for oral solution for 10 kg body weight per day for 3 days ( 1.5 – 2.66 gm / liter of drinking water /day for 3 days)

Calves, lambs, goats, pigs and rabbits: 2 to 2.5 grams of powder per 10 kg body weight per day in two equal doses for 3 days, orally in milk, milk replacer, the liquid food or drinking water.

Special warning for each target species:

NO.

Special precautions:

Special precautions for use in animals

This powder for oral solution is intended to be dissolved in milk, liquid food or drinking water and can not be used in the state.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

People with known hypersensitivity to polymyxin or trimethoprim should avoid contact with the veterinary medicinal product.

Handle this product by taking the recommended precautions to avoid any risk of exposure: the wearing of masks, goggles and protective gloves is recommended.

Contra – Indications:

Do not use in case of known allergy to trimethoprim.

Adverse effects:

Not known.

Withdrawal time:

Meat and offal : 7days

Do not use in laying birds producing eggs for consumption, four weeks before the start of laying and during it.

Storage conditions:

Store below 30 ° C in dry place, keep the container tightly closed and protected from light.

Packaging:

Plastic container:  50,100, 250, 500 gm, 1 kg and 5 kg.