Compostion:

Each ml contains:

Doxycycline (hyclate) …………………………… 100 mg

Bromhexine HCl…………………………………. 10 mg

Properties:

Doxycycline is a bacteriostatic antibacterial, acting by interfering protein synthesis in sensitive bacterial species. Doxycycline is a semisynthetic antibiotic belonging to tetracycline group, it acts on the 30 S subunit of the bacterial ribosome, which binds reversibly, blocking binding of aminoacyl-ARMT (transfer RNA) to the complex of mRNA and ribosome, preventing the addition of new amino acids to the growing peptide chain and interfering with the synthesis of proteins. It is active against Gram -positive and Gram-negative bacteria. Its antibacterial spectrum includes: Mycoplasma spp., Bordetella bronchiseptica, Pasteurella multocida and Mannheimia haemolytica.

Bromhexine is a benzylamine with expectorant properties. Used alone or combined with antimicrobial substances for the treatment of respiratory diseases where there is a mucocilary clearance and production of viscid mucous. Bromhexine increases the volume of bronchial secretion, modifies mucopolysaccharides produced by the secretory cells, reduces the viscosity of mucus and increases the trachiobrnochial ciliary activity.

Target species

Poultry (broilers), pre-ruminating calves and pigs.

Indications

Broilers chickens:

Treatment of chronic respiratory disease caused by mycoplasma and other bacterial organisms.

Pre-ruminating calves:

Treatment of respiratory infections caused by Pasteurella multocida and Mannheimia haemolytica susceptible to doxycycline.

Pigs:
Treatment of respiratory infections caused by Mycoplasma hyopneumoniae, Pasteurella multocida and / or Bordetella bronchiseptica sensitive to doxycycline.

Dosage & Administration

Route orally via drinking water

Broilers chickens:

1 ml of Bromodox oral solution / 10 kg b. w. / day (1 ml / liter of drinking water) for 4-5 consecutive days.

Pigs:
1 ml of Bromodox oral solution / 10 kg b. w. / day for 4-5 consecutive days.

The new medicated water should be prepared every 24 hours.

Pre-ruminating calves:

1 ml of Bromodox oral solution / 10 kg b. w. / Day for 4-5 consecutive days.

Once reconstituted milk (artificial), the solution should be consumed within 6 hours.

Precautions:

– Special warnings for each target species

Do not use this medicine in laying birds.

– Special precautions for use

– Special precautions for use in animals:

– For any infectious process is recommended bacteriological confirmation and performing

  diagnostic sensitivity test.

– Special precautions to be taken by the person administering the product.

• People with known hypersensitivity to tetracyclines should avoid contact with the
• veterinary medicinal product.
• Use personal protective equipment consisting of gloves, clothing and goggles approved to
• handling the product.

Avoid contact with skin and eyes in case of contact wash immediately with water.

Contra – Indications:

• Do not use in animals hypersensitive to tetracyclines to bromhexine or any of the
• Do not use in animals with hepatic disease.
• Do not use in animals with functional rumen.

Withdrawal Period :

Broiler chickens meat: 10 days.

Its use is unauthorized in laying birds producing eggs used for human consumption.
Do not use within 4 weeks from the start of laying.

Pre-ruminating Calves meat: 16 days.

Its use is unauthorized in lactating animals with their milk is intended for human consumption.

Pig meat: 10 days.

Adverse effects:

As in the rest of tetracyclines, allergic reactions may occur and photosensitivity.
In longer treatments for digestive disorders can appear dysbiosis intestinal.

Storage conditions

Store at temperature not exceeding 30 ºC and to be used immediately after opening.

Package

Plastic bottles:  100, 250, 500 ml and 1, 5 liter.