Composition:

Each 1 ml contains:

Difloxacin hydrochloride  ……………………………………….………..  109.13 mg

(Eq. to 100 mg Difloxacin base)

Properties:

Difloxacin can be bactericidal against many Gram-negative micro-organisms and a
selection of Gram-positive microorganism , The following organisms were tested and found to be susceptible to difloxacin in vitro :Escherichia coli, Klebsiella spp., Pasteurella spp., Pseudomonas spp., Staphylococcus intermedius. Difloxacin exert their antibacterial effects against both replicating and dormant microorganisms. Difloxacin acts primarily through inhibition of  bacterial DNA gyrase.

Target Species:

Dogs.

Indications:

For the treatment of :

-Acute uncomplicated urinary tract infections caused by Escherichia coli or Staphylococcus spp.

-Superficial pyoderma caused by Staphylococcus intermedius.

 Dosage & Administration:

Route orally via drinking water

For active ingredient :

The recommended dose of difloxacin base is 5 mg/kg bodyweight per day

For whole product:

1 ml /20 kg body weight given once a day for at least 5 days.  Superficial pyoderma may require treatment for up to a maximum of 21 days.

Precautions :

Heavy reliance on a single class of antibiotics may result in the induction of resistance in a bacterial population. It is prudent to reserve the fluoroquinolones for the treatment of clinical conditions that have responded poorly, or are expected to respond poorly, to other classes of antibiotic.

Contra – Indications:

– This product is restricted for use in dogs only

-As for other quinolones, due to possible adverse effects on the articular cartilage of weight bearing joints difloxacin should not be used during the rapid growth phase, that is, do not use in small and medium-sized breeds of dogs up to and including 8 months of age, in large breeds up to 1 year of age and in giant breeds up to 18 months of age.

-Do not use in epileptic dogs.

Withdrawal Period:

Not applicable.

Adverse  Effects:

Adverse reactions were rare in dogs treated with difloxacin. The observed reactions were inappetenc, emesis, diarrhea, and anal irritation. These adverse reactions were self-limiting within one or two days and did not require additional treatment.

Storage conditions:

 In cool and dry place away from direct sunlight.

Packaging:

Plastic bottles:  100 ml