Compostion:

Each ml contains:

Sulphadiazine …………………………….. 400.0 mg

Trimethoprim ……………………………… 80.0 mg

 Properties:

Sulfadiazine is a bacteriostatic antibiotic belonging to the sulphonamide group which acts by interference with the synthesis of nucleic acids. Trimethoprim is a dihydrofolate reductase inhibitor which also interferes with the synthesis of bacterial nucleic acids. Sulfadiazine and Trimethoprim are antibacterial for systemic use; the two active ingredients produce a sequential double blockade of bacterial synthesis of folinic acid, giving a level of activity many times greater than either drug alone. Folates are essential to the bacterial/protozoal cell for multiplication and survival. Sulphadiazine prevents the bacterial/protozoal cell from synthesising folic acid. Trimethoprim prevents the conversion of folic acid to folinic acid in the bacterial/protozoal cell, by inhibiting the bacterial/protozoal enzyme-dihydrofolate reductase. Because of their sequential action, trimethoprim and sulphonamides potentiate each other, greatly increasing their individual antibacterial effects. The action of this combination is bactericidal, whereas the components used separately are generally bacteriostatic. Potentiation is shown even against bacteria that are generally resistant to one or other of the components. The in-vitro activity covers most common Gram-positive and Gram- negative bacteria including: Escherichia coli and Salmonella spp.

Indications:

This product is indicated mainly for the treatment of outbreaks of primary bacterial diseases, but it may also be used for secondary bacterial infections associated with respiratory diseases in broilers and turkeys. It has a high degree of activity against

• coli septicemia, caused by Escherichia coli.
• Pullorum disease caused by Salmonella pullorum
• Fowl typhoid caused by Salmonella gallinarum
• Turkey cholera caused by Pasteurella infections.

Target Species:

Broiler chickens

Dosage of Administration:

Route:   Orally via drinking water

For whole product:

1 ml per 5 liters of drinking water for 5 days.

Special warning for target species

None.

 Special precautions

All other sources of water should be removed during the entire period of treatment.

Contra – Indications

Do not use in animals with known hypersensitivity to the active ingredient. Do not use in birds producing eggs for human consumption.

Adverse Effects

None reported.

Withdrawal time

Meat: 10 days.

Storage conditions

Do not store above 25°C. Store in a dry place. Protect from light. Do not freeze.

Packaging:

Amber glass bottles:  100, 250, 500 ml and 1 liter.