Composition:

Each 1gm contain :

Tylosin tartrate  ………………………………………………………………….   865.5  mg

(Eq .to  tylosin base 800 mg)

Properties:

Tylosin is a macrolide antibiotic produced by a strain of  streptomyces  fradiae . It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms. The tylosin spectrum of activity includes amongst others Gram-positive bacteria, some Gram–negative strains  such as pasteurella and  Mycoplasma spp.

In most species peak plasma concentrations have been attained 1 to 2 hours after oral administration of  tylosin. Compared to plasma levels clearly higher tissue concentrations have been observed.

Most of the residues are excreted in feces predominantly consisting  of tylosin (factor A) relomycin ( factor D ) and dihydrodesmycosin .

Indications

It is used for treatment :

• Chronic respiratory diseases (CRD) in broiler chickens and replacement chickens caused by Mycoplasma gallisepticum.
• Air saculitis in chickens caused by Mycoplasma synoviae.
• Infectious sinusitis in turkey caused by Mycoplasma gallisepticum.
• Necrotic enteritis in chickens caused by clostridium perfringes.
• For the prevention and control of enzootic pneumonia caused by Mycoplasma hyopneumoniae, swine dysentery caused by Brachyspira hyodysenteriae and other scours caused by organisms e.g. Lawsonia intracellularis sensitive to tylosin.
• Pneumonia in calves associated with Mycoplasma spp. and Pasteurella multocida sensitive to tylosin.

Target species:

Broilers and replacement chickens, turkeys, calves and pigs.

Dosage of Administration: 

Route:   Orally via drinking water

Broilers and replacement chickens and turkeys:  0.625 gm /1 liter of drinking water for 5 days.  (0.0625 gm/ kg b. wt.  for 5 days).

Pigs: 0.31 gm / liter of drinking water ( 0.0313 gm / kg. b. wt.) for 3-10 days.

Claves: 1.25 gm / calf twice daily for 7-14 days

Contra – Indications:

1-Do not use in animals with known hypersensitivity to tylosin or other macrolides .

2-Do not use in cases of known resistance to tylosin or cross-resistance to other macrolides (MLS-resistance)

3-Do not use in animals vaccinated with tylosin-sensitive vaccines either at the same time or within 1 week previously .

4-Do not use in animals with hepatic disorders .

5-Do not use in horses.

Adverse  Effects:

-There is no evidence of tylosin  toxicity in chickens , turkeys , pigs or calves when administered orally at up to three times the recommended dose .

-There is no evidence of tylosin toxicity in rats , at dose rates of up to 1000 mg/kg by the oral route .

 Withdrawal times :

Chicken (in case of necrotic enteritis) : zero day.

Chicken (in case of chronic respiratory diseases) : one day

Eggs: Not to be used in birds producing eggs for  human consumption.

Pigs: Slaughter withdrawal period nil.

Calves: Slaughter withdrawal period 14 days.

Storage conditions:

In cool and dry place away from direct sunlight.

Packaging:

Plastic container :  100, 250, 500 gm and 1kg .